Molecular staging individualizing cancer management
نویسندگان
چکیده
منابع مشابه
Molecular staging individualizing cancer management.
Although the most important prognostic and predictive marker in colorectal cancer is tumor cells in lymph nodes, approximately 30% of patients who are node-negative die from occult metastases. Molecular staging employing specific markers and sensitive detection technologies has emerged as a powerful platform to assess prognosis in node-negative colon cancer. Integrating molecular staging into a...
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The term “molecular staging” has been used to refer to the determination of tumor markers in the lymph tissue as an indicator of the presence of neoplastic cells. It is known that there are often minimal tumor cell foci or micrometastases (diameter less than 2 mm) which may be missed in the histopathological examination and that are usually only detectable by immunohistochemistry. Recently, new...
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The natural history of prostate cancer is notoriously variable and whilst some tumours remain indolent for many years, others result in rapid progression to metastasis and death. A substantial minority of patients treated with radical prostatectomy or radiotherapy with curative intent have rising levels of PSA in their serum after treatment, and this is often associated with the eventual develo...
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Many cancer prevention strategies are unlikely to provide equal risk reduction in all subjects, but instead are predicted to be particularly useful for specific individuals. An important research challenge is to devise methods for individualization of cancer prevention recommendations, such that particular interventions are assigned to those who will gain the most. Research in this area is at a...
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ژورنال
عنوان ژورنال: Journal of Surgical Oncology
سال: 2012
ISSN: 0022-4790
DOI: 10.1002/jso.21858